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Frequently Asked Questions about CoreCumin®, Curcumin, and Turmeric

Why should CoreCumin® be a part of my regular healthcare routine?

CoreCumin® is a form of curcumin that has been enhanced with our propriety platform technology, making it highly bioavailable and absorbable for the body. Our technology enables CoreCumin® to be very efficacious compared to other curucmin products on the market. Secondly, in many published studies, scientists worldwide have documented that curcumin can beneficially affect many conditions. Furthermore, placebo-controlled double-blinded randomized clinical trials have showed benefits of taking curcumin for: (1) the reduction of anxiety during depression and occupational stress (Lopresti & Drummond, 2017; Pandaran et al., 2016; Yu et al., 2015); (2) the improvement of fat metabolism in overweight/obese individuals with metabolic syndrome (Rahmani et al., 2016; Yang et al., 2014); (3) antioxidant effects following radiation therapy (Hejazi et al., 2016), osteoarthritis (Nakagawa et al., 2014; Panahi et al., 2016), and metabolic syndrome (Panahi et al., 2015); (4) reduction of inflammation in osteoarthritis (Rahimnia et al., 2015) and cancer (Panahi et al., 2014); (5) mediating remission of ulcerative colitis (Lang et al., 2015; Singla et al., 2014); (6) improves atherogenic blood markers in type II diabetes (Chuengsamarn et al., 2014); (7) reduces symptoms in women suffering from PMS (Fanaei et al., 2016; Khayat et al., 2015); and (8) augments the quality of life in cancer patients (Panahi et al., 2014).

References

Chuengsamarn, S., Rattanamongkolgul, S., Phonrat, B., Tungtrongchitr, R. & Jirawatnotai, S. (2014). Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial. J Nutr Biochem, 25, 144-150. doi: 10.1016/j.jnutbio.2013.09.013.

Fanaei, H., Khayat, S., Kasaeian, A. & Javadimehr, M. (2016). Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial. Neuropeptides, 56, 25-31. doi: 10.1016/j.npep.2015.11.003.

Hejazi, J., Rastmanesh, R., Taleban, F., Molana, S., Hejazi, E., Ehtejab, G., & Hara, N. (2016). Effect of curcumin supplementation during radiotherapy on oxidative status of patients with prostate cancer: A double blinded, randomized, placebo-controlled study. Nutr Cancer, 68(1), 77-85. doi: 10.1080/01635581.2016.1115527.

Khayat, S., Fanaei, H., Kheirkhah, M., Moghadam, Z., Kasaeian, A., & Javadimehr, M. (2015). Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial. Complement Ther Med, 23(3), 318-324. doi: 10.1016/j.ctim.2015.04.001.

Lang, A., Salomon, N., Wu, J., Kopylov, U., Lahat, A., Har-Noy, O., Ching, J., Cheong, P., Avidan, B., Gamus, D., Kaimakliotis, I., Eliakim, R., Ng, S., & Ben-Horin, S. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clin Gastroenterol Hepatol, 13(8), 1444-1449. doi: 10.1016/j.cgh.2015.02.019.

Lopresti, A. L. & Drummond, P. D. (2017).  Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. J Affect Disord, 207, 188-196. doi: 10.1016/j.jad.2016.09.047.

McFarlin, B., Venable, A., Henning, A., Best Sampson, J., Pennel, K., Vingren, J., & Hilla, D. (2016). Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin, 5, 72-78. doi: 10.1016/j.bbacli.2016.02.003.

Nakagawa, Y., Mukai, S., Yamada, S., Matsuoka, M., Tarumi, E., Hashimoto, T., Tamura, C., Imaizumi, A., Nishihira, J., & Nakamura, T. (2014). Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: A randomized, double-blind, placebo-controlled prospective study. J Orthop Sci, 19(6), 933-939. doi: 10.1007/s00776-014-0633-0.

Panahi, Y., Alishiri, G. H., Parvin, S. & Sahebkar, A. (2016). Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial. J Diet Suppl, 13(2), 209-220. doi: 10.3109/19390211.2015.1008611.

Panahi, Y., Saadat, A., Beiraghdar, F. & Sahebkar, A. (2014). Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: A randomized double-blind placebo-controlled trial. Phytother Res, 28(10), 1461-1467. doi: 10.1002/ptr.5149.

Panahi, Y., Hosseini, M., Khalili, N., Naimi, E., Majeed, M., & Sahebkar, A. (2015). Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr, 34(6), 1101-1108. doi: 10.1016/j.clnu.2014.12.019.

Pandaran Sudheeran, S., Jacob, D., Natinga Mulakal, J., Gopinathan Nair, G., Maliakel, A., Maliakel, B., Kuttan, R., & Im, K. (2016).  Safety, tolerance, and enhanced efficacy of a bioavailable formulation of curcumin with fenugreek dietary fiber on occupational stress: A randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol, 36(3), 236-243. doi: 10.1097/JCP.0000000000000508.

Rahimnia, A., Panahi, Y., Alishiri, G., Sharafi, M., & Sahebkar, A. (2015). Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: Findings from a randomized double-blind placebo-controlled trial. Drug Res (Stuttg), 65(10), 521-525. doi: 10.1055/s-0034-1384536.

Rahmani, S., Asgary, S., Askari, G., Keshvari, M., Hatamipour, M., Feizi, A., & Sahebkar, A. (2016). Treatment of non-alcoholic fatty liver disease with curcumin: A randomized placebo-controlled trial. Phytother Res, 30(9), 1540-1548. doi: 10.1002/ptr.5659.

Singla, V., Pratap Mouli, V., Garg, S., Rai, T., Choudhury, B., Verma, P., Deb, R., Tiwari, V., Rohatgi, S., Dhingra, R., Kedia, S., Sharma, P., Makharia, G., & Ahuja, V. (2014). Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - A randomized, placebo-controlled, pilot study. J Crohns Colitis, 8(3), 208-214. doi: 10.1016/j.crohns.2013.08.006.

Yang, Y., Su, Y., Yang, H., Lee, Y., Chou, J., & Ueng, K. (2014). Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Phytother Res, 28(12), 1770-1777. doi: 10.1002/ptr.5197.

Yu, J., Pei, L., Zhang, Y., Wen, Z., & Yang, J. (2015). Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: A randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol 35(4), 406-410. doi: 10.1097/JCP.0000000000000352.

When and how should I take CoreCumin®?

When you order CoreCumin®, you will receive a chart that gives you the daily serving amount based on body weight.  You can also look at that chart on our product pages. Preferably add the suggested number of drops to a glass of water and drink on an empty stomach (30 minutes before or 60 minutes after a meal) or as otherwise directed by your healthcare provider.  Spread intake over the day for maximum bioavailability.  Do not take with acidic foods, carbonated beverages, fruit juice, smoothies, other drinks with high levels of vitamin C, or carbonated drinks, as these may destabilize the curcumin micelles. Because CoreCumin® typically provides a boost in energy and focus for most people, it is best not to take it right before bedtime, as some customers have reported sleeplessness when doing so. If you are also taking CogniNurish®, we recommend that you take the two products 30 minutes apart.

Why should I choose CoreCumin® over other curcumin products?

While curcumin is quickly being recognized as a powerful phytonutrient for health, typical commercial curcumin products are limited in their effectiveness. Overall, other dietary supplement companies have tried to reap the benefits of curcumin and incorporate this compound into their products without much success. Curcumin is a fat-soluble (highly insoluble) molecule that is rapidly metabolized by our body (liver and intestine), which severely limits its therapeutic use.

In its extracted form, typically less than 10% of curcumin gets absorbed by the human body.  The rest either breaks down in the presence of enzymes in the liver and the intestine or gets rejected as waste. The difficulty in delivering curcumin limits its use, as it is very insoluble in water and is not well-absorbed by the human body. Thus, for therapeutic use, curcumin has to be administered in high doses. Even conventional emulsions and micro-emulsions are approximately 3,000 nm in particle size, which are not able to greatly enhance absorption or cellular penetration. Moreover, these formulations have limited stability and shelf life.

However, these limitations are now a thing of the past with Nurish.Me’s platform technology of using micelles in CoreCumin®! What is a micelle? A micelle is simply a complex that has an outer lipid membrane that contains an active ingredient on the inside of the membrane. It is also of a very small size, i.e., 5 nm. In comparison, your average red blood cell is about 8,000 nm, so this molecule is very small. The micelle enables the active ingredient to mostly bypass degradation by the digestive system to get into the bloodstream and out to the target cells where it can do its job. In CoreCumin®, the micelles are between 3-10 nm in diameter, which may be beneficial for enhanced absorption. This results in superior bioavailability of the final product ingredients. We are now able to solubilize curcumin and make it much more bioavailable to the human body in the highest quality form; a unique technological accomplishment within the market.  Nurish.Me’s ability to micellize curcumin without the use of prohibitive substances makes us the industry leader. Because of this breakthrough, CoreCumin® is better absorbed leading to higher levels of curcumin in the blood and tissues. Thus, a higher percentage of CoreCumin® is used by the cells without being wasted in the elimination process, which means greater efficacy and your satisfaction with our product!

Not only is CoreCumin® more bioavailable (i.e., more usable to your body) compared to the competition, but it also means that you do not need to take a mega dose of the active ingredient to get the same level of benefit. If your body uses 75%, 85%, or 90% of 100 mg of the bioactive curcuminoids, then that is far superior to it only using 10% of 1,000 mg in a product that is not formulated with micelles. This is a superior way to take your curcumin. In addition to the added health benefits, CoreCumin® is also more cost effective for you. Rather than taking another curcumin product that gets mostly excreted without benefit to you, your body will use the majority of CoreCumin®, so that you get the most "bang for your buck." This is important for anyone who strives to get the best quality in a product.

What will I notice once I start taking CoreCumin®?

Much like CogniNurish®, we expect that you may experience multiple benefits, i.e., a “white box effect” that provides previously unintended positive effects. As with CogniNurish®, CoreCumin® should help you with feelings of aches and discomfort, including muscle soreness following strenuous exercise. This is perhaps the most significant conscious benefit you will notice from our product. People also report sleeping better, waking up better refreshed, feeling more energetic, having no more “brain fog,” experiencing better digestion, feeling  sharper overall and more focused, and recuperating faster from jetlag. The effects vary per person, but typically manifest quite rapidly in most individuals. In dogs, pet owners have reported a reduction in soreness and healthier looking fur. Be careful that you do not get CoreCumin® on your clothes. It will stain, but we have found that OxiClean™ will remove it.

How many human studies have been conducted on curcumin?

Curcumin has been used in hundreds of clinical trials in humans, so it has a significant history.  Go to the following page on PubMed for a listing of many of those studies: https://www.ncbi.nlm.nih.gov/pubmed/?term=curcumin+clinical+trial+humans.

Multiple studies have shown the efficacy of curcumin, as explained by one of our co-founders and lead scientists in the top-tier journal Nature: https://www.nature.com/articles/543040c.

Reference

Heger, M. (2017). Drug screening: Don't discount all curcumin trial data. Nature, 543, 40.  doi: 10.1038/543040c.

How do I determine which curcumin product contains the highest amount of curcuminoids?

Curcumin (i.e., turmeric extract) dietary supplements contain more bioactive substances compared to turmeric dietary supplements at equal weight. For example, 100 mg of turmeric contains approximately 3 mg of curcuminoids. Alternatively, you would have to ingest 33 servings of turmeric (3.3 grams) to achieve an intake of 100 mg of curcuminoids. When assessing a product, first determine whether the product is comprised of turmeric or curcumin (i.e., turmeric extract). Then look for the amount of product per unit (e.g., one tablet, capsule, or drop) or serving. In the case of turmeric (powder), multiply the amount per unit or serving by 0.03 to arrive at the total curcuminoid content.

What is the difference between turmeric and curcumin?

Turmeric as a dietary supplement refers to the root of the Curcuma longa plant. About 3% of the root contains curcuminoids; a class of bioactive compounds in turmeric. Dietary supplements contain either turmeric, where the root has been ground to a powder, or curcumin, which has been extracted in purified form from the turmeric. Curcumin-based dietary supplements are often referred to as ‘turmeric extract.’

Where does turmeric grow and which countries produce turmeric?

Turmeric is indigenous to India and Southeast Asia. However, the plant also grows in other regions with a similar climate, including the northern part of South America. The majority of turmeric and curcumin used commercially comes from India, China, and Malaysia.

What is curcumin?

Curcumin is a bright yellow phytochemical produced by several species of the Curcuma genus, most notably Curcuma longa (also referred to as turmeric). Curcumin is the principal curcuminoid of turmeric root. Of the curcuminoids in turmeric root, curcumin comprises about 80%, followed by desmethoxycurcumin (~15%) and bisdemethoxycurcumin (~5%). Curcumin is marketed as a dietary supplement, food flavoring, food coloring, and cosmetics ingredient.

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